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HIV Testing Algorithms: A Status Report

Executive Summary     Full Document      Schematics      Key Data Needs     Questions?

The criteria for confirmation of HIV infection have remained unchanged since their establishment in 1989 by the Centers for Disease Control (CDC) and the Association of State and Territorial Public Health Laboratory Directors (now APHL). Updating the menu of options for HIV testing to incorporate new technologies is a high priority for the APHL/CDC HIV Steering Committee.

In August of 2006, the APHL/CDC HIV Steering Committee formed two multi-disciplinary workgroups with representatives from CDC, APHL, FDA, DOD, and both public health and commercial laboratories. These workgroups sought to develop optimal testing strategies for specific diagnostic needs and for use in the laboratory and at the point of care (POC).

These proposed testing strategies served as the basis for the content of the 2007 HIV Diagnostics Conference.  At that conference, researchers presented data that addressed the proposed algorithms as well as several challenges like the resolution of indeterminate or discordant test results and the detection of acute HIV-1 infection and HIV-2.  Based on these findings and other research, a summary report was developed on the status of the proposed algorithms and was issued in April 2009.  “HIV Testing Algorithms: A Status Report” thoroughly describes the proposed testing strategies, examines available data in support of the proposals, and identifies additional data needed to validate the algorithms. 

The call for abstracts for the 2010 HIV Diagnostics Conference again seeks to solicit data to fulfill the needs outlined in the Status Report.  Conference proceedings will guide the issuance of recommendations; development of a monitoring and evaluation plan; and drafting of messages appropriate for reporting by laboratories, interpretation by health-care providers and counselors, and communication to persons receiving test results.

Note that the publication of the strategies on this site does not constitute endorsement as final recommendations.  They are presented for the purpose of soliciting data and stimulating scientific discourse. The proposals do not represent any official determination or policy of CDC, APHL or any of the agencies represented in the workgroups.